It is a transparent negatively charged hydrogel that consists of only nanofibrillar cellulose (1.0% w/v) and purified water (99.0%) making it ideal for use in brightfield, phase contrast and fluorescence microscopy applications, as well as with high content imaging systems. GrowDex®-T is a bio-friendly hydrogel extracted from birch wood which is sourced from sustainable and responsibly managed forests. Here, a proof of concept study was performed to demonstrate the combination of GrowDex-T with the novel mini bioreactor system – VITVO, to recreate a complex layered structure.
As the field of regenerative medicine progresses, it is important to develop more physiologically relevant systems which closely mimic the diseased tissue and organs. They allow for the controlled delivery of nutrients and biomimetic stimuli for cell growth, differentiation, and tissue formation, whilst giving control over the spatiotemporal delivery of these biological, biochemical, and biophysical signals that regulate the cells and tissue development. Stella Frabetti1, Olivia Candini1, Elisa Gregianin1, Tony Kiuru2, Lauri Paasonen2, Jonathan Sheard2ġ3D Cell Culture Technologies R&D, Rigenerand srl, Medolla (MO), Italyīioreactors help to bridge the bench to bedside clinical translation of cell-based therapies with drug-testing platforms.
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